Date | Prof | Lab | Topic | Reading | |||||
Introduction | |||||||||
Jan.25 | SG ST | No lab this week | Introduction to neuroscience | Chapter 1 | |||||
27 | SG | Approaches to studying brain and behavior | Chapter 2 | ||||||
Development of the nervous system | |||||||||
29 |
SG | Neurohistology | Neurogenesis, migration | Chap. 7 (178-195); 23 (690-8) | |||||
Feb. 1 | Axon pathfinding; cell death | Chapter 23 (698-708) | |||||||
3 | Role of neural activity in development Hua JY, Smear MC, Baier H, Smith SJ. Regulation of axon growth in vivo by activity-based competition. Nature 434 (2005) 1022-1026 | ||||||||
Electrical signaling | |||||||||
5 |
SG | Electrophysiology | Membranes & membrane potentials |
Chapter 3 | |||||
8 | Action potential | Chapter 4 | |||||||
10 | Conductance mechanisms Stringer JL. Regulation of extracellular potassium in the developing hippocampus. Developmental Brain Research 110 (1998) 97‑103. | ||||||||
12
| ST | Outline of neuroanatomy | Chapter 7 (168-180; 193-199; 205-216; 227-235); Chapter 15 (490-498) | ||||||
Synaptic transmission | |||||||||
15 |
SG | Neuroanatomy I
| Chemical and electrical transmission | Chapter 5 (102-122) | |||||
17 | Postsynaptic potentials; neural integration | Chapter 5 (122-131) | |||||||
19 | ST | Neurotransmitter systems | Chapter 6; Chapter 15 (498-507) | ||||||
22 |
ST | Neuroanatomy II | Neurotransmitter systems (Cont,) | ||||||
24 | Morgan DG et al. Divergent changes in D-1 and D-2 dopamine binding sites in human brain during aging. Neurobiology of Aging 8 (1987) 95-201. | ||||||||
25/26 | Exam 1 | ||||||||
Sensory neuroscience | |||||||||
Mar.1 |
SG
| Neuroanatomy III | Vision: transduction; receptive fields | Chapter 9 (288-306) | |||||
3 | Visual information processing | Chapter 10 (310-329) | |||||||
5 | Visual cortex functions Chapter 10 (330-341) Ferster D, Chung S, Wheat H. Orientation selectivity of thalamic input to simple cells of cat visual cortex. Nature 380 (1996) 249‑52. | ||||||||
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8 |
SG | Lab practicals | Visual plasticity; critical periods | Chapter 23 (708-716) | |||||
10 | Somatosensory system | Chapter 12 (388-408) | |||||||
12 | Pain Chapter 12 (408-421) Eisenberger NI, Lieberman MD, Williams KD. Does rejection hurt? An FMRI study of social exclusion. Science 302 (2003) 290‑292. | ||||||||
[Spring break] | |||||||||
22
|
ST | Electrophysiology II | Chemoreception Chapter 8 Stratford JM, Curtis KS, Contreras RJ Chorda tympani nerve transaction alters linoleic acid taste discrimination by male and female rats. Physiology and Behavior 89 (2006) 311-319. | ||||||
24 | Auditory system I | Chapter 11 (344-375) | |||||||
26 | Auditory system II Zhang H, Cai R, Zhang J, Pan Y, Sun X Environmental enrichment enhances directional sensitivity of primary auditory cortical neurons in rats. Neurosci. Letters 463 (2009) 162-165. | ||||||||
Sensorimotor control systems | |||||||||
29 |
ST | Electrophysiology III | Spinal mechanisms | Chapter 13 | |||||
31 | Brain mechanisms Chapter 14 Perese DA, Ulman J, Viola J, Ewing SE, Bankiewicz KS. A 6-hydroxy-dopamine-induced selective parkinsonian rat model. Brain Research 494 (1989) 285-293. | ||||||||
Apr. 1/ 2 | Exam 2 | ||||||||
Neural basis of behavioral plasticity | |||||||||
5 |
SG | 6OHDA surgery | Human and animal memory | Chapter 24 | |||||
7 | Cellular mechanisms of neural plasticity | Chapter 23 (716-722); Chap. 25 | |||||||
9
| Does LTP underlie human and animal memory? Hu H, Real E, Takamiya K, Kang M, Ledoux J, Huganir RL and Malinow R. Emotion enhances learning via norepinephrine regulation of AMPA-receptor trafficking, Cell 131 (2007) 160–173. | ||||||||
Neuroendocrinology, Motivation, and Stress | |||||||||
12 | JPB | 6OHDA Lesions | Feeding behavior | Chapter 16 (510-531) | |||||
14 | ST | Endocrine systems | Chapter 15 (482-490) | ||||||
16 | Sexual behavior Chapter 17 (541-561) Patisaul HB, Fortino AE, Polston EK. Neonatal genistein or bisphenol-A exposure alters sexual differentiation of the AVPV. Neuro-toxicology and Teratology 28 (2006) 111-118. | ||||||||
19 |
ST | Behavior /c-fos | Stress I | Chap. 15 (491-496); 18 (573-582); 22 (668-670) | |||||
21 | Stress II Yaka R et al. Effect of varied gestational stress on acquisition of spatial memory, hippocampal LTP and synaptic proteins in juvenile male rats. Behavioural Brain Res. 179 (2007) 126-132. | ||||||||
22/23 | Exam 3 | ||||||||
Diseases of the nervous system | |||||||||
26 |
ST | HPLC | Addiction Cruz FC, Marin MT, Planeta CS. The reinstatement of amphetamine-induced place preference is long-lasting and related to decreased expression of AMPA receptors in the nucleus accumbens. Neuroscience 151 (2008) 313-319. | ||||||
28
| Depression Chapter 22 (673-678) Hattori, S., et al. Enriched environments influence depression-related behavior in adult mice and the survival of newborn cells in their hippocampi. Behavioural Brain Res. 180 (2007) 69-76. | ||||||||
30 | RF | Neurodegenerative diseases: Huntington’s and ALS Guest lecture by Dr. Robert Ferrante, Jr. | |||||||
3 |
ST | Data dicussion
| Schizophrenia Chapter 22 (678-685) Flagstad P, Glenthoj BY, Didriksen M. Cognitive deficits caused by late gestational disruption of neurogenesis in rats: a preclinical model of schizophrenia. Neuropsychopharmacology 30 (2005) 250-260. | ||||||
5
| SG | Alzheimer disease Box 2.3 p. 36-37 Verret L, Jankowsky JL (’91), Xu GM, Borchelt DR, Rampon C.. Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease. Journal of Neuroscience 27 (2007) 6771-6780. | |||||||
7 |
| Review/catchup day |